Viral Email Marketing: How To Make Your Emails Viral And Outrageously Profitable

Viral email marketing is one of the most popular means of promoting your products or services. You can easily contact several thousands – or even millions – of individuals at one time and have them spreading your email message, promoting your business and generating income for you.

It is important that you understand the mechanics of viral email marketing to take advantage of its full potentials, and get the cash your business needs at a fraction of the usual time and effort.

What is Viral Email Marketing?

Viral marketing is one of the most efficient marketing tool innovated in the online industry. The term was coined after the idea of an information spreading quickly and effectively. In offline marketing industry, viral marketing is what is often referred to as “word-of-mouth” marketing strategy, which is considered by some marketing experts as the most effective type of marketing.

Viral email marketing is a branch of a variety of viral marketing tools and techniques that internet marketers can use these days. Although the benefits are quite appealing, there are certain techniques that online marketers need to follow closely in order to reap those benefits.

Since most people these days utilize their email to communicate on a daily basis, it is where viral email marketing is targeted. You can therefore appeal to every individual in your target market specifically, which when done correctly, have higher potential of generating sales.

If you were to recall the history of email marketing campaigns, it all started with Hotmail. They offered clients who availed of their service a free email account. For every online businessmen though, you can offer a variety of techniques to your prospects through their email that will enable you to utilize the power of this technology to spread the word about your marketing campaign.

Viral Email Marketing Techniques

The techniques you use in your viral email marketing campaign depends largely on your business goals. In most cases, the goals of an online marketer when sending out emails to the people in their mailing list is to inform them about a particular product or information. A subset to this goal is to compel them to forward the message or email to their friends in their email list, thus spreading the word about your line of products.

Why would your prospects forward the email they receive? The key here is to send them emails that are of some level of worth. If not, then it would probably take them a shorter amount of time to delete the email message than they would reading what the content of the mail is.

One effective way to increase readership is to carefully consider the information value or entertainment value you input in the content of your email message. Being informative does not necessarily mean your email message has to be dull. Learn how to infuse some creativity into it. With proper use of useful or amusing content, you will most likely compel people in your mailing list to read your emails and forward them to people who might benefit from them.

Prior to this stage though, you need to have had proper methods of building a large opt-in list. The methods you use must also be targeted, such that the people in your mailing list are most likely to respond to your viral email marketing campaign.

Subject Line of a Viral Email

Although this comes prior to the actual opening of your emails, this is incredibly important. The subject line is the first thing that a person sees whenever they open their inbox. There are only two options for them: to click on the mail you sent or not. Hence, it is important that you convince them to do the former. One technique is to keep your subject line interesting or provoke curiosity.

Using the “Open Me” or “Read Me” approach is fast becoming ineffective. Plus, it is a very lazy approach at convincing people to actually read the mail. Try to keep your subject line short but snappy for higher effectiveness.

Content of a Viral Email

You have three options in terms of how you build the content for your viral email marketing: sales letter, newsletter, or review format. Regardless of your choice of content format, you need to keep it brief yet ample in scope. Remember, people browsing the internet have short amount of patience and you need to feed them the information they need within the shortest time possible.

If you find that the message is too long but all parts are too relevant to omit, consider sending them in parts. This is also an effective way to rouse the reader’s interest.

Another way to convince them to click on the links you provided is by offering them a valuable and tangible object. It does not need to be a lucrative object but must be something of value or usefulness to them. This helps further an effective viral email marketing that produces real results.

Timing or Frequency in Sending Out Viral Emails

Here is another important component for an effective viral email marketing campaign. If you have set the schedule for the broadcast of your viral email messages using an autoresponder, make sure to limit the amount of emails you send the people in your mailing list.

Three times a week should be substantial to advance your viral email marketing, but there are always exceptions to the rule. The key is to be sensitive to the needs and desires of your audience, and to offer them the right amount of information at the right moments.

Overdoing it can result to annoyance on the part of your readers and cause them to opt-out of their subscription. Or worse, they could spread the word about their dissatisfaction, which could negatively affect your reputation.

After all, an effective viral email marketing campaign is built more around the powerful messages you send them, rather than the frequency of emails on their inbox.

Immobilienmakler Heidelberg

Makler Heidelberg



Source by Jeremy Gislason

Link Building Strategy for Self Managed SEO

A well thought through and planned link building strategy is essential before embarking on a self managed link building campaign. The following post will outline a basic strategy that can be used for your website.

Remember – every website should be treated individually so whilst this may work for one, it may be too much or too little for others.

Link building packages generally consist of a variety of link types. This is done deliberately as Google and other search engines do not favour one particular type of link, they like a variety from differing page sources. We will highlight how to use each product to formulate a link building strategy that may work for your website.

Directory Submissions

Web directory submissions are a quick and cost effective way of building some link popularity for your site. They are by no means the route to all our link building goals but they are a steady basis – we see them as always happening behind the scenes.

We would generally submit your website homepage to web directories as certain webmasters do not accept deep links – An expected acceptance rate from manual directory submission is 60%.

Directory submission sites range from well established high PR directories like DMOZ to new, up and coming directories that will pass the link juice over a longer period. As the vast majority are manually approved, acceptance can take between 12 hours and 6 months!

We would generally submit the directories at around 100-200 per week and use no more than 10 different anchor texts – We would generally concentrate on the highest competition phrases with the directories to build weight to the home page.

Social Bookmarking

Social Bookmarking is a great way of achieving deep links from high PR websites. As a lot of these are also high traffic sites, social bookmarks give you the chance to put your bookmark in front of a potentially large audience dependent on your niche.

Social bookmarking sites generally have an instant approval rate as user accounts are required to access the submission areas.

On the major social bookmarking sites – the Digg’s, the Stumbleupon’s of the world – the links are nofollow links – they do not pass any of the link weighting across and these are usually avoided in SEO. Social bookmarking sites counter this by placing your link in front of a potentially large audience searching in your niche.

Social bookmarking is an ongoing process and is often used to target the niche phrases contained on the pages deep within your website. – An example could be www.site.co.uk/productname with the product name as the title of the bookmark.

Article Marketing

Article marketing is a proven way of adding good authority to your website – as long as you are marketing the correct content! With between 300 and 500 words the norm for the majority of article submission websites, there is usually plenty of information within your company to write your own article. We offer an article writing service using SEO trained UK journalists as the copywriters.

The article is placed on a page of its own and generally with no other content on the page (adverts and navigation excluded). This gives you a very content rich page linking back to your website.

The links in article marketing are usually found in the author’s bio section of the article. A general rule is that 2 links are allowed – generally a high competition phrase to your homepage and a deep link to the page on your site the articles are targeting.

Theme Based Link Building

Theme based link building is the most search engine friendly link building technique available. When used correctly, it can reap benefits; when done wrong, it can be a very expensive mistake both to your company cash and also your website’s reputation.

Theme based link building is used to help target very high competition search phrases and are done in much smaller numbers than any of the services mentioned above. With an average link price of £10, theme based links are used sparingly – unless you have the budget of course.

Conclusion

Mix it up – don’t just concentrate on one link source – what if the algorithm changes?

Ask us!! We provide a submission service but we can also manage all your link building needs – from one site to a large portfolio. We tailor every strategy for your needs – be they financial or rankings.

Manual Link Building provide SEO services through link building including social bookmarking, article marketing and directory submissions . View and buy online here.

Immobilienmakler Heidelberg

Makler Heidelberg



Source by Gareth Hoyle

SEO: What is meant by SEO?

SEO stands for Search Engine Optimization. In The industrialized world of where Internet hold a very good and important position in world of marketing there only websites can’t be enough to increase the sales and all others thing.

Building a very impressive and good looking website is useless there no traffic on the site it’s same like a road which a no traffic to run on it is useless. TO solve this problem the term Search Engine Optimization was introduced in internet world also known as SEO in mid – 1990s SEO is the process to increase the amount of incoming traffic to a particular website from search engines via unpaid search results as opposed to Search Engine marketing (S E M) which deals with paid inclusion.

The search engines usually display result according to user’s input and the earlier or higher on the search page more are the chances of that the more users will follow the website link. Search engines use user rating method to place the site at top and bottom for certain search input. User could use SEO to target many types of searches like Images, Local search, Video Search, News, Industry specific vertical search.

As an Internet marketing strategy, SEO considers how search engines work and what people search for. Optimizing a website primarily involves editing its content and HTML and associated coding to both increase its relevance to specific keywords and to remove barriers to the indexing activities of search engines.

The acronym “SEO” can refer to “search engine optimizers,” a term adopted by an industry of consultants who carry out optimization projects on behalf of clients, and by employees who perform SEO services in-house. Search engine optimizers may offer SEO as a stand-alone service or as a part of a broader marketing campaign.

Because effective SEO may require changes to the HTML source code of a site, SEO tactics may be incorporated into web site development and design. The term “search engine friendly” may be used to describe web site designs, menus, content management systems, images, videos, shopping carts, and other elements that have been optimized for the purpose of search engine exposure. In Early Years of SEO the webmaster needed to submit the address of a page or URL to various search engines.

The search engines would then send a spider or crawler to crawl the page extract the link of the other pages on the site and return the result to the search engine which is later indexed. In this process a spider sent by search engine download the page extract certain words and their position and weight and is stores into a scheduler for crawling at a later date.

By 2004, search engines had incorporated a wide range of undisclosed factors in their ranking algorithms to reduce the impact of link manipulation. Google says it ranks sites using more than 200 different signals. The leading search engines, Google and Yahoo, do not disclose the algorithms they use to rank pages.

Notable SEOs, such as Rand Fishkin, Barry Schwartz, Aaron Wall and Jill Whalen, have studied different approaches to search engine optimization, and have published their opinions in online forums and blogs. SEO practitioners may also study patents held by various search engines to gain insight into the algorithms.

In 2005 Google began personalizing search results for each user. Depending on their history of previous searches, Google crafted results for logged in users.

In 2008, Bruce Clay said that “ranking is dead” because of personalized search. It would become meaningless to discuss how a website ranked, because its rank would potentially be different for each user and each search.

In 2007 Google announced a campaign against paid links that transfer PageRank.[14] In 2009 Google disclosed that they had taken measures to mitigate the effects of PageRank sculpting by use of the nofollow attribute on links.

In December 2009 Google announced it would be using the web search history of all its users in order to populate search results.

SEO is a critical part of running website. It is best left to the experts who understand the notion of NICHE websites and finding a niche keyword to market.

Immobilienmakler Heidelberg

Makler Heidelberg



Source by Marc Trimble

Article Submission – Automatic Or Manual Method?

When considering submitting articles to article directories, there are two ways to achieve this. The first one is to use an automatic submission using one of the software programs available.

There are several hundred directories available to submit articles, and using an automatic service will save a lot of time, but there are disadvantages to using this method as well.

One of the main reasons for submitting articles in to get one-way links back to websites and this helps to obtain better positioning in search engines.

The problem with automatic article submission is that many of the best article directories do not like this method. Also there are differences with article directories in their submission guidelines.

Some directories allow html in the article content, others don’t. Sometimes it is possible to put links in the content but many directories will not allow this.

There is a difference in the number of links allowed between article directories. There is a difference in the information required for submissions, including entering categories and sometimes-requiring image confirmation to submit articles.

The number of words allowed varies from the different directories. The correct category must be chosen, the correct number of links added.

Manual article submission will offer the best results, because using automatic submission some directories will not accept the article.

Using the manual method, the article can be changed to best suit each directory; the number of links can be varied to get the maximum benefit for each article. The category can be selected which best fits each article, and this can make a big difference in the results obtained from articles.

The articles have a much better chance of acceptance using manual submission as the correct category has been chosen, the right amount of links added and number of words.

Many of the top directories will only accept articles, which have been manually submitted.

There are many companies who now offer article submission services who charge per article or for a group of articles. When choosing to use this method, it is important to see which directories the articles will be submitted to and to receive a report of successfully submitted directories.

It is important not to submit an article more than once to the same directory; so careful recording of all results must be obtained.

When deciding which method to use for article submission, it will be important to consider a few points like how much time you have to do this yourself, remembering that it will take around five minutes to submit to one directory.

It may be beneficial to use a manual submitting service to do this for you. It will be an additional expense but this can be offset by the time saved.

Maybe a combination of manual and automatic submissions could provide the best solution depending on a particular situation.

Immobilienmakler Heidelberg

Makler Heidelberg



Source by John Sullivan

Proper Seam Pressing in Quilts

Pressing the seams in your quilt is one of the most important tasks for the completed work. A good press will mean that the quilt is assured a smooth flow from piece to piece both visually and to the touch. Most quilters will find that they have a style of pressing that suits them best, but before you find that style it is important to realize what pressing is not.

What Pressing is Not

Pressing the seams in your quilt is not the same as ironing. Although you will be using an iron and an ironing board, it is absolutely critical to remember that you are not ironing (that is, running the appliance over the seam with gentle pressure) but just coaxing the seam down in order to seal it and make it less visible.

Pressing the seam is often thought of as a way of strengthening the seam, but this is not really the case. No strength is added to the seam itself by having it seam pressed down; instead, pressing the seam will mean that should any stitch come undone, the cotton batting in the quilt will not push up through the seam. This can be said to strengthen the integrity of the quilt somewhat, but it does not make the seam itself any stronger.

What Pressing Is

Pressing uses the weight of the iron itself to create seam allowances that might otherwise result in lost fabric. In a work such as a quilt, which requires many pieces put together, lost millimeters on each piece can mean a big difference in the end product. Pressing quilt blocks as they are made eliminates this problem.

Pressing will also create a good loft which will come in handy when it comes time to attach the pieces. Finally, pressing will help give the quilt a uniform appearance and feel. The fabric should never cover the seam on a properly pressed quilt.

Types of Pressing

There are two types of pressing; side pressing and open pressing. Side pressing is simply pressing the seams to one side, and is generally advocated by most quilting instructors.

Open pressing involves application of the iron both to the back and the front of the blocks. This can take twice as long as side pressing, but those who use it say that it greatly helps in the appearance of the quilt. This style is most appropriate when using machine stitched pieces, which are stronger than those done by hand; the stitch is less likely to come undone, and therefore hiding a hole will not be necessary.

Pressing Technique

When you are pressing blocks in the full quilt, the seams should be pressed towards the dark patches. If your quilt involves a more intricate pattern, with spirals and compass shapes, then try pressing in a clockwise pattern; at the very least, make sure that your presses are all uniform in direction. This will lessen the bulk in the middle of the pattern when all the seams are pressed.

Pressing seams is probably one of the dullest aspects of quilting, but it is important to make sure that you do it accurately. It will help to maintain the integrity of the quilt and can also make piecing that much easier.

One last hint, don’t use steam! The heat from the iron will be sufficient for pressing. Moisture may cause colors to run, and will make the blocks more susceptible to distortion.

Immobilienmakler Heidelberg

Makler Heidelberg



Source by Jan Myers

Free Reverse Phone Directory – "Free You Say"

A free reverse phone directory is more or less similar to a normal telephone directory offering details regarding a telephone user. A reverse phone directory differs from the normal telephone directory in that, here customers search the directory with telephone numbers as the search item to get key information such as the name and address of the telephone user. This is just the reverse of the popular name-based phone number searching in normal telephone directories. Hence the name reverse phone directory.

Today a number of free reverse phone directory services are available for users, with the majority of them offering their services online. Almost all free reverse phone directories allow their customers to search details regarding a telephone number by just entering the area code and the telephone number as the inputs. These directory services then search their database with the users input number and instantly provide clients with various details such as name and street address of the telephone owner, the name of phone carrier provider, and whether the number is a landline number or a wireless number.

The benefits of using such reverse phone directories vary according to the needs. As most free reverse phone directory service providers keep their clients searches private and confidential, users can search for personal information regarding telephone numbers without having to reveal their identity. These free reverse phone directories provide information regarding the source of threatening and harassing phone calls one may have received. You can also locate those anti-social characters, who play pranks on you over the phone. Moreover, you can find details about unknown numbers on your telephone bill and obtain information on numbers stored on your caller ID phone.

Most of these free reverse phone directory services get their data from government and public documents, demographic information, from periodicals and magazines, and also from third parties. With an increasing number of free reverse phone directory services now offering online services with customization to specific regions and states, users now have easier and free access to the information they require.

Even though it is the commercial reverse phone directory service providers who give more detailed information, the basic details provided by free reverse phone directories are sufficient to obtain the required information about a person or business firm. Although most reverse phone directory services provide accurate information, it is wiser to double check the identity of retrieved information such as personal names as there may be people with identical names residing in the same area or home. So a detailed personal inquiry can help you a great deal, in case you may have to take legal action in cases regarding telephone misuse.

Immobilienmakler Heidelberg

Makler Heidelberg



Source by Ben Levanger

California Pedestrian Accident Statistics

When cars collide with pedestrians, there is high potential for serious injury. Pedestrian/motor vehicle accidents are a serious problem throughout the world. The United States has a particular problem with pedestrian deaths and injuries. About 5,000 pedestrians are killed and another 64,000 are injured in motor vehicle accidents every year in this country.

The following represents pedestrian accident statistics for the United States according to the National Highway Traffic Association and the Insurance Institute for Highway Safety.

– Pedestrian fatalities account for 11 percent of motor vehicle fatalities.
– Over 180,000 pedestrians have been killed in motor vehicle accidents between 1975 and 2005.
– Pedestrians comprise the second largest category of motor vehicle accident deaths following occupant deaths.
– On average, a pedestrian is injured in a traffic accident every 8 minutes.
– On average, a pedestrian is killed in a traffic accident every 111 minutes.
– In 2005 a total of 4,881 pedestrian were killed in motor vehicle accidents.
– In 2005, the per capita pedestrian death rate was 1.6 per 100,000 people.

Generally, pedestrian deaths rates are higher in urban areas. There is a higher ratio of deaths to injuries in rural areas because of higher impact speeds on rural roads. However, pedestrian accidents occur most frequently in urban areas because pedestrian activity and traffic volumes are greater compared to rural areas.

The National Safety Council estimates that 85.7 percent of all non-fatal pedestrian accidents in the United States occur in urban areas and 14.3 percent occur in rural areas.

– Almost two-thirds of all pedestrian fatalities occur on urban roads.
– In 2005, 72 percent of pedestrian deaths occurred in urban settings.

Although a substantial number of pedestrian injuries occur at intersections, the majority of pedestrian accidents occur at locations other than intersections. This is due to higher vehicle speeds and the fact that drivers are not expecting any stops.

– Over 40 percent of the fatalities in 2002 occurred on roads without crosswalks.
– In 2003, 65 percent of accidents involving pedestrians occurred at non-intersections.
– In 2005, 71 percent of pedestrian deaths occurred on major roads, including interstates and freeways.

Statistically, males are more likely to be involved in a pedestrian/motor vehicle accident than females.

About 69 percent of pedestrian fatalities are male, and the male pedestrian injury rate is approximately 58 percent higher than for females.

– In 2005, 70 percent of pedestrian deaths were comprised of males.
– In 2003, the male pedestrian fatality rate per 100,000 population was 2.27 – more than double the rate for females which was 1.01 per 100,000 population.

The vast majority of fatal pedestrian/motor vehicle collisions occur on Friday, Saturday, and Sunday in later evening hours.

In 2005, the proportion of pedestrian deaths was much greater on Friday and Saturday. Also, 45 percent of the pedestrian deaths in 2005 occurred between 6 pm and midnight.

– In 2005, 49 percent of all pedestrian fatalities occurred on Friday (17 percent), Saturday (18 percent), or Sunday (14 percent).
– In 2005, 24 percent of pedestrian deaths occurred from 6 pm-9pm and 21 percent occurred from 9pm-midnight.

Young children and the elderly are the most vulnerable for pedestrian accident related injuries. Based on population, children under the age of 16 years are most likely to be struck by motor vehicles.

– In 2003, nearly one-fifth of all traffic fatalities for victims under the age of 16 were pedestrians.
– In 2003, almost one-forth of all traffic fatalities for children between 5 and 9 years old were pedestrians.
– In 2002, 40 percent of all pedestrians under the age of 16 occurred between 5 pm and 9 pm.

Elderly pedestrians, although struck less frequently than children, are more likely to die after being struck by a vehicle. This group accounts for 16 percent of all pedestrian fatalities and 6 percent of all pedestrian injuries.

– In 2005, the rate of pedestrian deaths per 100,000 people was about twice as high for people age 70 and older than for those younger than 70 – 2.9 per 100,000 population.
– In 2005, 35 percent of pedestrian deaths among people 70 and older occurred at intersections, compared with 21 percent for those younger than 70.

Speeding is a major contributing factor in motor vehicle accidents of all types and has serious consequences when a pedestrian is involved.

At higher speeds, motorists are not as likely to see a pedestrian. At higher speeds, motorists are even less likely to be able to stop in time to avoid hitting a pedestrian.

– A pedestrian has an 85 percent chance of death when involved in a motor/vehicle collision at 40 mph, a 45 percent chance of death at 30 mph, and a 5 percent chance of death at 20 mph.
– In 2005, 78 percent of pedestrian deaths in rural areas occurred on roads with speed limits of 40 mph or higher.

When a pedestrian is involved in a motor vehicle accident they are at risk for countless serious injuries. Pedestrians’ head, legs, and arms are the most vulnerable in an accident. Often, pedestrians endure extreme bodily injuries such as:

– Traumatic brain injury
– Spinal cord injury
– Paraplegia
– Quadriplegia
– Coma
– Fractured bones

Most pedestrians are struck by the front of a passenger vehicle. The initial contacts are with the vehicle bumper and/or the front edge of the hood, depending on the shape of the vehicle structure. When pedestrians are struck by taller vehicles such as SUV’s or pickup trucks, the initial contacts are higher on the body.

In an NHTSA pedestrian accident study, 40 percent of pedestrian injuries resulted from contact with the vehicle, 32 percent resulted from contact with the ground, and 26 percent resulted from contact with unknown objects.

– For a young child, the bumper will strike the thigh, and the front edge of the hood will strike the torso.
– For an adult male, the bumper will strike the knee area, and the front edge of the hood will strike the thigh.

There are numerous common factors that contribute to pedestrian accidents. Negligence is one of the most common factors. Motorists have a responsibility to adhere to the laws of the road and drive in a safe and observant manner at all times. Pedestrians are killed every day due to a driver’s negligence.

Some common negligent practices by motorists include:
– Inattentive or pre-occupied drivers are potentially very dangerous for pedestrians.
– A driver’s failure to observe posted speed limits can add to the severity in a pedestrian/motor vehicle accident.
– A driver’s failure to yield the right of way to pedestrians at marked cross walks can increase the chance of being involved in a pedestrian/motor vehicle accident.
– A driver’s disregard for traffic control devices can also increase the chance of being involved in a motor/vehicle accident.

There are many things that can be done to reduce pedestrian collisions. Improving the design and materials of roadways and implementing educational and community programs have great potential.

Some of the most important categories of engineering changes that can be made to roadways include separation of pedestrians from vehicles by time or space, measures that increase the visibility and conspicuity of pedestrians, and reduction of vehicle speeds. Separation countermeasures reduce the exposure of pedestrians to potential harm on the roadside and when crossing the street.

Some effective separation countermeasures include:
– Sidewalks
– Overpasses
– Underpasses
– Refuge islands in the medians of busy two-way streets

Increased illumination and improved signal timing at intersections can be effective in increasing the visibility and conspicuity of pedestrians.

Some measures to increase the visibility and conspicuity of pedestrians include:

– Increased intensity of roadway lighting
– Diagonal parking
– Relocation of bus stops at traffic signals from the near to the far side of the intersection

Because traffic speeds affect the risk and severity of pedestrian accidents, reducing speeds can reduce pedestrian deaths.

Some effective engineering measures to reduce vehicle speeds in urban areas include:

– Construction of modern roundabouts in place of stop signs and traffic signals
– Traffic calming devices such as speed humps
– Multiway stop signs

Educational and community-based programs could greatly reduce the number of pedestrian collisions.

Educational messages that instruct children about street crossings could particularly reduce neighborhood accidents involving children darting out into the street.

Community-based programs could contribute by building and refurbishing playgrounds in urban areas to reduce the number of children playing in the streets. The establishment of supervised recreation programs would also reduce the number of children playing in the streets.

Long-term data shows a declining trend in pedestrian/motor vehicle collisions. Since 1975, pedestrian deaths have declined from 17 percent to 11 percent in 2005.

The rate of pedestrian deaths per 100,000 people decreased from 3.5 in 1975 to 1.6 in 2005. Even though the annual number of pedestrian accidents is slowly decreasing, the fact remains that there are 69,000 pedestrian accidents annually.

Young children and the elderly have always held the highest risks of pedestrian death and injury. Change and progress must be a priority for as long as it takes to eliminate pedestrian collisions altogether.

Immobilienmakler Heidelberg

Makler Heidelberg



Source by John Bisnar

Viral Structure Of Hsv


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HSV-1 and HSV-2 are two of the eight known viruses which comprise the HSV family. As with all herpes viruses, they are large, enveloped visions with an icosahedral nucleocapsid consisting of 162 capsomeres, arranged around a linear, double-stranded DNA core. The genome consists of two covalently linked components, designated L (long) and S (short).

Each component consists of a unique sequence flanked by inverted repeats. Additionally, the unique L and S components can invert relative to one another, yielding four linear isomers. Each intact HSV vision contains only one of these four isomers, and each of the four is equally virulent (functionally equivalent) in the host cell.

The DNAs of HSV-1 and HSV-2 are largely collinear, and considerable homology exists between the HSV-1 and HSV-2 genomes. These homologous sequences are distributed over the entire gnomic map, and most of the polypeptides specified by one viral type are antigenically related to polypeptides of the other viral type.

This results in considerable cross-reactivity between the HSV-1 and HSV-2 glycoproteins, although unique antigenic determinants exist for each virus. Viral surface glycoproteins mediate HSV attachment to and penetration into cells and provoke host immune responses. Eleven glycoproteins of HSV have been identified (gB, gC, gD, gE, gG, gH, gI, gJ, gK, gL, and gM).

In addition, a twelfth is predicted (gN). gD is the most potent inducer of neutralizing antibodies and appears related to viral entry into a cell, and gB also is required for infectivity. Antigenic specificity is provided by gG, with the resulting antibody response allowing for the distinction between HSV-1 (gG-1) and HSV-2 (gG-2).

Two biologic properties which directly influence human disease are latency and neurovirulence. During HSV infection, visions are transported by retrograde flow along axons that connect the point of entry into the body to the nuclei of sensory neurons. Viral multiplication occurs in a small number of sensory neurons, and the viral genome then remains in a latent state for the life of the host.

With periodic reactivation brought on by events such as physical or emotional stress, fever, UV light, and tissue damage, the virus is transported back down the axon to replicate again at or near the original point of entry into the body. Such reactivation can result in clinically apparent disease or clinically inapparent infection.

The mechanisms by which HSV establishes latency are being intensely investigated but remain incompletely understood. Neurovirulence refers to the affinity with which HSV is drawn to and propagated in neuronal tissue. This can result in profound disease with severe neurologic sequelae, as is the case with neonatal HSV central nervous system (CNS) disease and with herpes simplex encephalitis in older children and adults.

Sites on the HSV genome which mediate this propensity for neurovirulence have been mapped to the thymidine kinase gene as well as the termini of the L component. Of note, the gene is required for replication in central nervous system tissue and prevents apoptosis of infected neuronal cells. Genetically engineered HSV visions lacking the gene are currently being investigated as therapies for brain tumors.

HSVCurative is used specifically to treat HSV1 and HSV2 infections and acts as a curative agent against both these strains of herpes. It exhibits a pronounced anti-herpetic activity against HSV1 and HSV2 and, unlike other cures for herpes, actually kills these viruses upon exposure regardless of location on the body.

HSVCurative is formulated at maximum strength and has produced spectacular results above other potential herpes cures in eliminating herpes outbreaks in almost all known cases of use on herpes. It is possibly the most powerful and effective topical herpes treatment on the market, providing total clearance of outbreaks time after time.

HSVCurative contains certified organic medicinal plant extracts and antiviral essential oils which cause cellular death to HSV. HSVCurative has a rather remarkable array of pharmacological and biochemical properties which inactivate and destroy the herpes virus for unprecedented results compared to other cures for herpes. To learn more, please go to http://www.bcured.net.

Immobilienmakler Heidelberg

Makler Heidelberg



Source by bcured

Network Marketing Internet Business – Become Visible Online Now

A business is not a business without exposure. In order to be successful, we must understand the importance of being seen and heard of. One of the best things about a network marketing internet business is that there are several different ways to gain exposure.

Keywords for your Page

If you are like most people, you spend a great deal of time searching the web. In order to search the web, you have type in the term that you are searching for into the search bar. The search engine then scans millions of websites that contain that term or phrase that you searched for. When it comes to a network marketing internet business, this is the best way to get your page found by web surfers and search engines. You must first remember to register your website with the search engines. The top search engines that most people in America use are Google, Yahoo, DMOZ, Librarians Internet Index, and Alexa. When you are creating content for your website, be sure to include keywords.

Words to Use

How do you know what keywords are appropriate? First, think about the content of your site. If it is a network marketing site, or affiliate website, then you will want to make use of the terms commonly used to search for the type of content your page displays. Put yourself on the other side of the fence when creating content and keywords. If you were looking for an online business in network marketing or affiliate marketing, what terms would you type in your search bar to find the right website to direct you? You would probably type something like, “how to become a network marketer” or “sign up to affiliate program”. It is really quite easy once you get the hang of it.

One thing that you can do to make sure that your page gets maximum exposure is to first type in the terms that you plan to use in your page. This will help you to get a good idea of who your competition is. Take a look at the first few pages that display on Google, Yahoo, or any of the other search engines. Examine how they used their keywords. Determine the placement of your keywords and the amount of times you will need to use your keywords in order to gain the same amount of exposure.

Make use of your Online Signature

Each time that you send an email or leave a post on an online forum, make sure to insert your signature along with a link to your site. People are interested in looking other people’s websites when they visit online forums. Sometimes, the only reason why people look at forums is to get some ideas of how to make their own website. They are also great resources for easily finding other network marketers.

The Beauty of Business Cards

You might think that they are a waste of time and money, but something that people can actually hold,touch, and see might be able to gain your more exposure than the internet. People associate business cards with professionalism and high quality business. They will not just see you as another struggling blogger trying to gain exposure, they will see you as a professional business person. Presenting people with your business cards also gives them the luxury of looking at your website when they have the time. They will not feel as forced to view your site as they might with some other methods.

All it takes is a little time and effort to be seen. New websites are making it to the front page all of the time. All of the while, others are using the wrong methods and being too forceful with their tactics. Do not try to force your page onto anyone. Never attempt to force someone to look at your site. That is a business no-no. By remaining professional in your efforts, people will begin to feel drawn to your business. Keep persistent and use the above mentioned strategies for maximum exposure potential.

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Makler Heidelberg



Source by Aaron Alexandra Ngoh Kwong Meng

Submission: A Novel

Submission: A Novel

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A controversial, intelligent, and mordantly funny new novel from Frances most famous living literary figure

It’s 2022. François is bored. He’s a middle-aged lecturer at the New Sorbonne University and an expert on J. K. Huysmans, the famed nineteenth-century novelist associated with the Decadent movement. But François’s own decadence is of considerably smaller scale. He sleeps with his students, eats microwave dinners, and watches YouPorn.

Meanwhile, it’s election season, and in an alliance with the Socialists, France’s new Islamic party sweeps to power―and Islamic law is instituted. Women are veiled, polygamy is encouraged, and François is offered an irresistible academic advancement―on the condition that he converts to Islam.

A darkly comic masterpiece from one of France’s great writers, Submission by Michel Houellebecq has become an international sensation and one of the most discussed novels of our time.

Picador USA



Immobilienmakler Heidelberg

Makler Heidelberg